Process synthesis tissue plasminogen activator

Example of Process Synthesis Manufacture of Tissue Plasminogen Activator (tPA)... 

As shown for the manufacture of tissue plasminogen activator (tPA) in Section 3.4, when batch operation is selected for an equipment item, either the batch time or batch size must be selected, with the other determined as a function of the throughput specification (e.g., 80 kg/yr of tPA). Furthermore, for a single-product plant involving a serial sequence of processing steps, when the product throughput is specified, the throughput for each process unit is determined, as shown in the synthesis of the tPA process in Section 3.4. In many cases, available vessel sizes are used to determine the size of a batch. 

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