Process analytical technology tools

T.R.M. De Beer, W.R.G. Baeyens, J. Ouyang, C. Vervaet and J.R Remon, Raman spectroscopy as a process analytical technology tool for the understanding and the quantitative in-line monitoring of the homogenization process of a pharmaceutical suspension. Analyst, 131, 1137-1144 (2006). 

Tang, X. C., Nail, S. L, Pikal, M. J., 2006a. Evaluation of manometric temperature measurement, a Process Analytical Technology tool for freeze-drying. Part I Product temperature measurement. 

The chemometric basic tools may be divided into the following typologies of study data exploration, modelling, prediction and validation, design of experiments (DOE), process analytical technology (PAT), quantitative structure-activity relationship (QSAR). Details and relevant literature are reported in the following paragraphs. 

Raman spectroscopy was discovered over 75 years ago but has only been a viable process tool for 10-15 years. However, there has been an astounding increase in process Raman spectroscopy examples in the last five years. The United States Food and Drag Administration s (US FDA) endorsement of process analytical technology clearly set off an explosion of activity. Problems that sometimes sidelined Raman in the past, such as fluorescence or highly variable quantitative predictions from samples that were too small to be representative, are being re-examined and leading to new technology. In turn, that helps open, or perhaps reopen, new application areas. The availabihty of easy to use Raman instrumentation at many prices also helps with that. 

J.C. Menezes, P. Felizardo and M.J. Neiva-Correia, The use of process analytical technology (PAT) tools in biofuels production. Spectroscopy, (9), 30-35 (2008). 

S. E. Gilbert, The future of liquid-phase microseparation devices in process analytical technology, in Micro Instrumentation for High Throughput Experimentation and Process Intensification - a Tool for PAT, M.V. Koch,... 

Process analytical technology (PAT) continues to evolve and develop, with new tools and more areas of implementation constantly emerging. In such a dynamic area, it is difficult to be current on all that is new. It is exciting to be able to present a second edition of this book, in an effort to cover some of the more recent advances in the five short years since the release of the first edition. 

CHEMICAL IMAGING AND CHEMOMETRICS USEFUL TOOLS FOR PROCESS ANALYTICAL TECHNOLOGY... 

Lewis, N., Schoppelrei, J., Lee, E., and Kidder, L. (2005), Near-infrared chemical imaging as a process analytical tool, in Bakeev, K. A., Ed., Process Analytical Technology, Blackwell, London, pp. 187-225. 

Yves Roggo, F. Hoffmann-La Roche, Ltd., Basel, Switzerland, Process Analytical Technology Chemical Imaging and Chemometrics Useful Tools for Process Analytical Technology... 

Raman Spectroscopy A Strategic Tool in the Process Analytical Technology Toolbox... 

Commit to employing innovative quality control tools, such as process analytical technologies. 

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