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Problem Hydrolysis of Acetylcholine

Acetylcholine is a neurotransmitter, particularly important in the stimulation of muscle tissue. The transmission of an electric impulse to the end of the nerve causes it to release acetylcholine molecules onto the surface of the next cell, and hence stimulating it. After such release, the acetylcholine is quickly broken into acetate and choline, which is passed back to the first cell to be recycled into acetylcholine again. The poison Curare acts by blocking the transmission of acetylcholine. Some nerve gases operate by preventing the breakdown of acetylcholine, thus causing continual stimulation of the receptor cells, which leads to intense spasms of the muscles, including the heart. [Pg.118]

Measuring the disappearance of acetylcholine gives us the following data  [Pg.118]

Demonstrate that the hydrolysis of acetylcholine can be treated as a pseudo-first order reaction. [Pg.118]

Second order reaction with different reactants [Pg.119]

For the disappearance of A we can write the general second order rate equation  [Pg.119]


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Hydrolysis of acetylcholine

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