Probabilistic Methods for Hazard Assessment

Probabilistic methods can be applied in dose-response assessment when there is an understanding of the important parameters and their relationships, such as identification of the key determinants of human variation (e.g., metabolic polymorphisms, hormone levels, and cell replication rates), observation of the distributions of these variables, and valid models for combining these variables. With appropriate data and expert judgment, formal approaches to probabilistic risk assessment can be applied to provide insight into the overall extent and dominant sources of human variation and uncertainty. 

Toxicological Risk Assessments of Chemicals A Practical Guide 

Alarie, Y. 1973. Sensory irritation in the upper airways by airborne chemicals. Toxicol. Appl. Pharmacol. 24 279-297. 

Alarie, Y. 1981. Bioassay for evaluating the potency of airborne sensory irritants and predicting acceptable 

Alarie, Y. 2007. Yves Alarie (Alarie test) website, www.yvesalarie.com 

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