Priority ratings

Table 9.2 Years from first-into-man studies to NDA submission and from submission to approval by period of submission and FDA priority rating ...

Table 5.9 Hypothetical example of the priority-rating scheme used to compare two substances - clear cells correspond to regulatory action indicators and shaded cells to probability indicators - ratings are shown in bold italics...

The 33 chemicals can be broadly divided between high , medium and low priority ratings, as indicated by the shading in Figure 6.2. 

Information from EU risk assessment reports used to carry out the priority ratings is detailed in the original publication of this thesis in 2007. 

It is apparent from Figure 6.2 that there are no instances of a risk with a high overall priority rating for the extent of action and low rating for the probability of a regulatory response needing to occur, or vice versa. This can be explained by ... 

A molecule such as 14 is said to have two enantiotopic faces. Attack by, say, LiAlH4 at the Re face will produce one enantiomer, and attack at the Si face will produce the other. There is no correlation between the configuration of the carbonyl face and that of the tetrahedral product after addition of a reagent. It all depends on the priority rating of the added reagent with respect to the groups in the original carbonyl compound. 

This gives a numeric value to each of the hazards which, as well as highlighting the highest risk, provides the basis for a priority rating. 

The properties of particulate fillers in a number of other thermoplastics are being investigated by plastics producers and academic institutions but usually with a low priority rating. This activity has been growing less and less in recent years as companies, in particular, have been reducing the staffing levels in the research and development departments. 

For its official communications the OPCW shall enjoy, in the territory of the State Party and as far as may be compatible with any international conventions, regulations and arrangements to which the State Party adheres, treatment not less favourable than that accorded by the Government of the State Party to any other Government, including the latter s diplomatic mission, in the matter of priorities, rates and taxes for post and telecommunications, and press rates for information to the media. 

When considering priority ratings it is useful to determine a key which will give a numerical indication of the recommended speed of action. While there are a number of such recording mechanisms available a large proportion will base themselves on similar ratings to those indicated in Table 14.2. 

Having recorded the recommendations and assigned a priority rating, ideally the action plan should enable a specific named person, or a key role, e.g. human resources manager for training requirements, within an organisation to be nominated to take responsibility for implementing the recommendations contained within the action plan. 

In terms of prioritisation an initial review as to the potential for those with physical disabilities to work on the ground floor (until such time as remedial actions can be implemented) required the provision of evac chairs and training with a Priority 3 rating, together with raising staff awareness, plus the review of the policy with a Priority rating of 3/4 and the provision of an evacuation lift (Priority 5). 

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