Principle of minimum chemical distance

Jochum C, Gasteiger J, Ugi I, Dugundji J (1982) The principle of minimum chemical distance and the principle of minimum structure change, Z Naturforsch 37B 1205... 

Principle of minimum chemical distance 1980 Jochum, Gasteiger, and UgiP... 

Solid-state photoreactions are featured by their chemo-, regio-, and stereoselectivities, which are often quite different from those in solution (1). These features originate from the crystal structure of the parent molecule that is ordered with respect to packing, distance, mutual orientation, space symmetry, and molecular conformation. Reactions in crystals normally proceed with a minimum of atomic and molecular movement as a result of physical restraints by the crystal lattice (topochemi-cal principle) (2). To predict and control the crystal structure and reactivity by designing a chemical structure (crystal engineering) is one of the most attractive challenges in modern solid-state photochemistry (3). 

ECOTOX-SSAR Principle 5 may be assured by the selection of the manifested chemical-eco-(bio-)binding parallels the minimum distances of paths (Putz M.V., Lacrama, 2007 Putz, 2012a-b)... 

Nevertheless, when thinking to a mechanistic interpretation of the computed models and of the associate endpoints the least, or minimum, action principle within the spectral norm-cut-off time abstract space has to be consider. That would require that shortest distance between two endpoints spectral norm and cut-off times implies the first chemical-biological interaction. Therefore caution has to be paid to not confound the maximum-correlation factor-maximum-spectral norm-and-cut-off time behaviour with the minimum distance between such spectral norm-cut-off time points in the abstract endpoint space. 

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