Primary Toxic Reaction in Unsensitized Guinea Pigs

Macher and Sennlaub (1963) also injected DNCB into the lymph nodes (0.1% to 5% or 65 y to 3550 y per guinea pig). They obtained 50 sensitized guinea pigs out of 118 (solution used for the test 0.1 and 0.25% DNCB in alcohol). [Pg.7]

Bj splenic administration. Grimmer (1961) obtained a sensitization by injecting in the spleen 900 y of DNCB in alcohol. [Pg.7]

By intravenous or intracardiac administration. This method is of no interest (Landsteiner and Jacobs, 1935 Landsteiner and Chase, 1940). [Pg.7]

Intradermal injections, combined with the application of a DNCB solution on the skin of guinea pigs, induce an appreciable sensitization (Landsteiner and Chase, 1937). This technique has been produced by many authors, either with DNCB, or with other allergens. We have also employed it for citraconic anhydride (p. 32) and propionic anhydride (p. 35). [Pg.7]

These methods have been especially developed by Landsteiner and Jacobs (1936), Landsteiner and Chase (1940, 1941) and Chase (1954) There are 3 preparations for the injection [Pg.7]

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