Primary cutaneous disease, treatment

Gene delivery to, or via, the skin has three principal objectives a) the treatment of primary cutaneous diseases and wounds, b) inducing skin cells to encode a protein which is subsequently released into the systemic circulation in a controlled fashion, and c) immunization. The first two instances involve a chronic delivery challenge, whereas immunization requires only acute exposure to the DNA involved. 

Common causative organisms in adults with canaliculitis include Staphylococcus aureus and Actinomyces species. Primary herpetic infections (herpes simplex, varicella, and vaccinia) have a higher prevalence among patients younger than age 20 years and often present with cutaneous manifestations of the infectious disease. Chronic allergies may also be associated with canalicular obstruction. Occasionally, patients may suffer from canalicular obstruction as a result of topical antimetabolite treatment such as 5-fluorouracil or mitomycin C. 

---