Prianos

Ohtani, I. Ichiba, T. Isobe, M. Kelly-Borges, M. ScheuCT, P.J. (1995) Kauluamine an unprecedented manzamine dimer from an Indonesian marine sponge, Prianos sp. J. Am. Chem. Soc., 117, 10743-4. 

Discorhabdins A (8), B (9) and C (10) have been isolated from several sponge species of the genus Latrunculia from New Zealand. They are powerful cytotoxins with IC50 values against the murine leukemia P-388 cell line in the range 0.03 - 0.01 pg/ml. Discorhabdin A has also been isolated from a Japanese sponge of the genus Prianos [29]. 

These complex sulfide-containing pyrroloiminoquinone alkaloids consist of the prianosins A-D (52, 53, 56, 57), isolated from the Okinawan Prianos melanos [54, 55], the discorhabdins A and B (52, 54), obtained from three different species of the New Zealand Latrunculia [56], discorhabdin D (57) from Latrunculia brevis and Prianos sp. [57], and discorhabdin Q (55), from Latrunculia purpurea, and several species of... 

Discorhabdin and related pigments have been isolated from temperate and tropical sponges of the genera Latrunculia, Prianos, Zyzzya, and Batzella 94 discorhabdin C (Structure 7.11)95 and G (Structure 7.12)38 were recently found in Latrunculia apicalis collected from McMurdo Sound.96 Discorhabdins often bear significant cytotoxicity. Discorhabdin C is perhaps the strongest sea star deterrent studied to date and displays broad spectrum antibiotic activity toward sympatric bacteria.38 96... 

C. Priano, F. R. Kramer, and D. R. Mills, Cold Spring Harbor Symp. Quant. Biol. 52, 321 (1987). 

Priano LL Effect of halothane on renal hemodynamics during normovolemia and acute hemorrhagic hypovolemia. Anesthesiology 1985 63(4) 357-63. 

Jarnberg PO, Marrone, B, Priano, LL. Enflurane preserves renal blood flow. Anesthesiology 1990 73 A572. 

Priano LL. Effectsof high-dose fentanyl on renal haemodynamics in conscious dogs. Can Anaesth Soc J 1983 30(1 ) 10-8. 

An unprecedented manzamine dimer, kauluamine (90), was isolated from the Indonesian marine sponge Prianos sp. 90 is an unsymmetrical dimer composed of tetracyclic and pentacyclic ring systems. Efforts to obtain a crystalline structure or to run an INADEQUATE experiment were unsuccessful. Thus the structure was elucidated by NMR methods, mainly on the basis of extensive 2D-NMR experiments, DQFCOSY, HOHAHA, HMQC, HMBC, and HMQC-HOHAHA [102,103]. 

Kauluamine An unprecedented Manzamine Dimer from an Indonesian Marine Sponge, Prianos sp. Ohtani L L Icchiba, T. Isdbe M. Kelly-Borges, M. and Scheuer P. Tennen Yuki Kagobutsu Toronkai 1995, 37, 236. 

In 1987, Kobayashi et al. reported on the isolation of a novel alkaloid, prianosin A (481), from the Okinawan marine sponge Prianos melanos (204). The methanol-toluene extract of the green sponge, which was collected at a depth of 2 to 3 meters in the Motobu Peninsula of the Okinawa Island, was partitioned between toluene and water. The water layer was extracted with chloroform and extensive column chromatography afforded prianosin A (481) (0.02%, wet wt.). 

Kobayashi J, Cheng JE, Ishibashi M, Nakamura H, Ohizumi Y, Hirata Y, Sasaki T, Lu H, Clardy J (1987) Prianosin A, a novel antileukemic alkaloid from the okinawan marine sponge Prianos melanos. Tetrahedron Lett 28 4939 942... 

Perry NB, Blunt JW, Munro MHG (1988) Discorhabdin D, an antitumor alkaloid from the sponges Latrunculia brevis and Prianos sp. J Org Chem 53 4127 128... 

Cheng J, Ohizumi Y, Walchli MR, Nakamura H, Hirata Y, Sasaki T, Kobayashi J (1988) Prianosins B, C, and D, novel sulfur-containing alkaloids with potent antineoplastic activity from the Okinawan marine sponge Prianos melanos. J Org Chem 53 4621 624... 

Parodi A, Priano L, Rebora A. 1991. Chronic zinc deficiency in a patient with psoriasis and alcoholic liver cirrhosis. Int J Dermatol 30 45-47. 

Sigmosceptrellin (6) and muqubilin (7) are norsesterterpene peroxides which we reisolated from the Red Sea sponges Sigmosceptrella and Prianos sp., and previously described by Kashman and Rotem in 1979, and by Albericci and co-workers 3 years later. The structural similarity to the artemisinins, which peroxide moieties contribute to their antimalarial activity, suggests that the antimalarial activities of these compounds may be... 

M.R. Gasco, L. Priano, G.P. Zara, Chapter 10—solid lipid nanoparticles and microemulsions for drug delivery. The CNS, Prog. Brain Res. 180(2009) 181-192. 

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