Prianos melanos

These complex sulfide-containing pyrroloiminoquinone alkaloids consist of the prianosins A-D (52, 53, 56, 57), isolated from the Okinawan Prianos melanos [54, 55], the discorhabdins A and B (52, 54), obtained from three different species of the New Zealand Latrunculia [56], discorhabdin D (57) from Latrunculia brevis and Prianos sp. [57], and discorhabdin Q (55), from Latrunculia purpurea, and several species of... 

In 1987, Kobayashi et al. reported on the isolation of a novel alkaloid, prianosin A (481), from the Okinawan marine sponge Prianos melanos (204). The methanol-toluene extract of the green sponge, which was collected at a depth of 2 to 3 meters in the Motobu Peninsula of the Okinawa Island, was partitioned between toluene and water. The water layer was extracted with chloroform and extensive column chromatography afforded prianosin A (481) (0.02%, wet wt.). 

Kobayashi J, Cheng JE, Ishibashi M, Nakamura H, Ohizumi Y, Hirata Y, Sasaki T, Lu H, Clardy J (1987) Prianosin A, a novel antileukemic alkaloid from the okinawan marine sponge Prianos melanos. Tetrahedron Lett 28 4939 942... 

Cheng J, Ohizumi Y, Walchli MR, Nakamura H, Hirata Y, Sasaki T, Kobayashi J (1988) Prianosins B, C, and D, novel sulfur-containing alkaloids with potent antineoplastic activity from the Okinawan marine sponge Prianos melanos. J Org Chem 53 4621 624... 

Prianos melanos Cheng et al, 1988b Kobayashi et al, 1991e... 

Cheng, )., Ohizumi, Y, Walchli, M.R., Nakamura, H., Hirata, Y, Sasaki, T., and Kobayashi, J. (1988b) Prianosins B, C, and D, novel sulfurantineoplastic activity from sponge Prianos melanos. J. Org. Chem., 53, 4621-4624. 

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