Latrunculia apicalis

Discorhabdin alkaloids, Fig. (31), in contrast, are of high cytotoxicity, but they exhibit no inhibition of topoisomerase II. They were isolated from the Anthartic sponge Latrunculia apicalis [238], and more recently from a deep-water marine sponge of the genus Batzella sp. [239], The new discorhabdin derivative isolated from this sponge showed in vitro cytotoxicity against tumor cell lines. 

Yang A, Baker BJ, Grimwade J, Leonard A, McClintock JB (1995) Discorhabdin Alkaloids from the Antarctic Sponge Latrunculia apicalis. J Nat Prod 58 1596... 

Furrow FB, Amsler CD, McClintock JB, Baker BJ (2003) Surface Sequestration of Chemical Feeding Deterrents in the Antarctic Sponge Latrunculia apicalis as an Optimal Defense Against Sea Star Spongivory. Mar Biol 143 443... 

Discorhabdin and related pigments have been isolated from temperate and tropical sponges of the genera Latrunculia, Prianos, Zyzzya, and Batzella 94 discorhabdin C (Structure 7.11)95 and G (Structure 7.12)38 were recently found in Latrunculia apicalis collected from McMurdo Sound.96 Discorhabdins often bear significant cytotoxicity. Discorhabdin C is perhaps the strongest sea star deterrent studied to date and displays broad spectrum antibiotic activity toward sympatric bacteria.38 96... 

Yang, A., Chemical and biological studies of the antarctic sponge Latrunculia apicalis, Master s thesis, Florida Institute of Technology, Melbourne, FL, 1994. 

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