Prianos species

Manes et al. (110) isolated two substances from an undescribed Prianos species. While the major compound was a or-sesterterpene which will be discussed in the next section together with other sesterter-penes, the minor one was a or-diterpene peroxide, methyl nuapapuan-oate (142). Capon and Macleod (110a) obtained another r-diterpene peroxide (143) from an unidentified sponge. 

Discorhabdins A (8), B (9) and C (10) have been isolated from several sponge species of the genus Latrunculia from New Zealand. They are powerful cytotoxins with IC50 values against the murine leukemia P-388 cell line in the range 0.03 - 0.01 pg/ml. Discorhabdin A has also been isolated from a Japanese sponge of the genus Prianos [29]. 

These complex sulfide-containing pyrroloiminoquinone alkaloids consist of the prianosins A-D (52, 53, 56, 57), isolated from the Okinawan Prianos melanos [54, 55], the discorhabdins A and B (52, 54), obtained from three different species of the New Zealand Latrunculia [56], discorhabdin D (57) from Latrunculia brevis and Prianos sp. [57], and discorhabdin Q (55), from Latrunculia purpurea, and several species of... 

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