Preparation of lithium amide bases

5 Preparation of lithium amide bases (e.g. lithium diisopropylamidep J[ BuLi/THF 

Lithium amide reagents are very sensitive to moisture and they must be prepared very carefully if they are to be used successfully. A few simple precautions should ensure that the preparation is successful  

Make sure you are familiar with the principles outlined in Section 9.4.1 on low temperature reactions before you start The simple apparatus shown in Fig. 9.20 can be used for the preparation of lithium amide bases. 

For most purposes it is reasonable to assume quantitative formation of LDA using this method, consequently if the i butyl lithium solution has been accurately titrated, the amount of LDA formed should be known, however if problems are encountered there are procedures available to check the titre of the LDA itself.5 

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