Preparation of 4-Bromo-2-Chloroaniline

Concenfrafed hydrochloric acid is a corrosive liquid, and 14 A/aqueous sodium hydroxide is highly caustic. Wear latex gloves when handling these chemicals and thoroughly wash any areas of your skin that may come in contact with them. 

Preparation Sign in at www.cengage.com/login to answer Pre-Lab Exercises, access videos, and read the MSDSs for the chemicals used or produced in this procedure. Review Sections 2.9, 2.11, 2.17, and 2.22. 

Apparatus A 250-mL round-bottom flask, apparatus for heating under reflux, magnetic stirring, vacuum filtration, and flameless heating. 

Setting Up Mix 11.2 g of crude 4-bromo-2-chloroacetanilide with 20 mL of 95% ethanol and 13 mL of concentrated hydrochloric acid in the flask. Add a stirbar and assemble the apparatus for heating under reflux. 

Hydrolysis and Isolation Heat the mixture under reflux for ca. 0.5 h. At the end of this period, add 90 mL of bof water, swirl the mixture to dissolve any solids completely. 

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