Preparation by oxidation of alcohols

Evidence for the structure (CXXIII) of the hemiacetal is based on the extremely hindered nature of the derived aldehyde (CXXV) and carboxylic acid (CXXVII). Thus, the aldehyde exhibited a negative Cotton effect in methanol, which remained unchanged upon the addition of hydrochloric acid, indicating great resistance toward acetal formation. Attempts to prepare carbonyl derivatives of this aldehyde were unsuccessful. The acid CXXVII was prepared by oxidation of alcohol CXXIV with chromium trioxide in acetic acid. Comparison of the apparent dissociation constant of this acid (pX cs 9.45) with that for... 

Aldehydes and ketones can be prepared by oxidation of alcohols or alkenes by the partial reduction of carboxyhc acid derivatives (aldehydes only) or by hydration of alkynes. 

Aldehydes and ketones may be prepared by oxidation of alcohols. If the product is to be a ketone, the alcohol must be a secondary alcohol, in which the hydroxyl group is bonded to an interior carbon ... 

This section describes an important synthesis of alcohols reduction of aldehydes and ketones. Later, we shall see that aldehydes and ketones may be converted into alcohols by addition of organometallic reagents, with resulting formation of a new carbon-carbon bond. Because of this versatility of aldehydes and ketones in synthesis, we shall also illustrate their preparation by oxidation of alcohols. 

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See also in sourсe #XX -- [ , , , , ]

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