Preliminary Database Creation

Having completed an initial assessment of the primitive design problem and having conducted a literature search, the design team normally seeks to organize the data into a compact database, one that can be accessed with ease as the team proceeds to create process flow- 

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The development of an alternative method begins with the creation of a test followed by generation of a database that supports its utility. This work provides the preliminary evidence that a method is reproducible and has predictive capability. Once available, this information can be used to construct a prediction model that describes how to convert the results from an alternative method into predictions of toxicity in vivo. When a method has been technically advanced to this point, it may be assessed in the validation process. 

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