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Pregnanetriol,urinary

The following procedure was developed for urinary pregnanediol, pregnanetriol, and 17-ketosteroids in urine. It is similar to the one presented earlier for pregnanediol (12). Hydrolysis is complete because sulfatase for the cleavage of sulfates is included with the B-glucuronidase. [Pg.510]

Fia. 9. The urinary excretion of certain steroids in an infant with a deficiency of 21-hydroxylase. The filled-in columns indicate the steroid excretion while the infant was receiving therapy with cortisone and fluorocortisol. 21-OH-pregnenolone and pregnanetriol were identified by mass spectrometry. The unidentified compound reacts with blue tetrazolium and has a polarity similar to 21-OH-pregnenoIone. [Pg.194]

As Brooks (B25) has pointed out, urinary steroid estimations may be classified according to the amount of purification necessary prior to GLC. For example, in the estimation of pregnanediol in pregnancy a fairly simple extraction and clean-up of the hydrolyzed urine is all that is needed before application of GLC, whereas the analysis of estrogens in nonpregnancy urine requires extensive purification procedures prior to GLC. Estimation of pregnanetriol in nonpregnancy urine provides a case which is intermediate between these two examples. [Pg.237]

Figure 1. Profiles of urinary estradiol and pregnanetriol (center) througout the year 2002. The composition of urinary volatiles was compared by SPME and GC-MS. The total ion chromatogramms (TIC) of four selected samples are shown including the sample taken on the day of the estrogen increase (11 April), which is dominated by the appearance of fatty acids (Cs, Cio, Cu). Figure 1. Profiles of urinary estradiol and pregnanetriol (center) througout the year 2002. The composition of urinary volatiles was compared by SPME and GC-MS. The total ion chromatogramms (TIC) of four selected samples are shown including the sample taken on the day of the estrogen increase (11 April), which is dominated by the appearance of fatty acids (Cs, Cio, Cu).
Figure 1 GC-MS Profile analysis. Total ion chromatogram profiles produced by scanning methoxy-trimethylsilyl derivatives of urinary steroids. (A) Profile from a patient with 11 -hydroxylase deficiency in which the principal steroids are metabolites of IIjS-deoxycortisol (substance S) such as tetrahydrosubstance S (THS) and hexahydrosubstance S epimers (HHS). (B) Profile from the patient s father this profile is essentially normal. Some of the major metabolites are C19 steroids such as androsterone (An), et-iocholanone (Etio), pregnanetriol (PT), and cortisol metabolites (THE, tetrahydrocortisone THF, tetrahydrocortisol and 5a-THF, 5a-tetrahydrocortisol). Peaks 1-3 are internal standards. (Reprinted from Shackleton CHL, Merdinck J, and Lawson AM (1990) In McEwan CN and Larsen BS (eds.) Mass Spectrometry of Biological Materials, pp. 297-377. New York Dekker courtesy of Marcel Dekker Inc.)... Figure 1 GC-MS Profile analysis. Total ion chromatogram profiles produced by scanning methoxy-trimethylsilyl derivatives of urinary steroids. (A) Profile from a patient with 11 -hydroxylase deficiency in which the principal steroids are metabolites of IIjS-deoxycortisol (substance S) such as tetrahydrosubstance S (THS) and hexahydrosubstance S epimers (HHS). (B) Profile from the patient s father this profile is essentially normal. Some of the major metabolites are C19 steroids such as androsterone (An), et-iocholanone (Etio), pregnanetriol (PT), and cortisol metabolites (THE, tetrahydrocortisone THF, tetrahydrocortisol and 5a-THF, 5a-tetrahydrocortisol). Peaks 1-3 are internal standards. (Reprinted from Shackleton CHL, Merdinck J, and Lawson AM (1990) In McEwan CN and Larsen BS (eds.) Mass Spectrometry of Biological Materials, pp. 297-377. New York Dekker courtesy of Marcel Dekker Inc.)...
Determination of Urinary Pregnanolone, Pregnanediol and Pregnanetriol by Gas-Liquid Chromatography... [Pg.1]

Cas-Liquid Chromatography of Urinary 17-Keto Steroids, Pregnanediol, and Pregnanetriol in Normal Individuals Am. J. Clin. Pathol. 48(2) 216-224 (1967) CA 68 19108s... [Pg.41]

Routine Gas-Liquid Chromatographic Method for Simultaneous Assay of Major Urinary 17-Ketosteroids, and Pregnanediol and Pregnanetriol... [Pg.113]

Gas Chromatographic Estimation of Urinary Pregnanetriol, Pregnane-triolone, and Pregnanetetrol in Congenital Hyperplasia J. Clin. Endocrinol. Metab. 26(11) 1219-1226 (1966) CA 66 27221x... [Pg.136]

A Modified Method for the Analysis of Urinary 17-Keto Steroids, Pregnanediol and Pregnanetriol by Gas-Liquid Chromatography in Normal Subjects and Subjects with Various Endocrine Disorders Acta Endocrinol. (Copenhagen) 54(1) 37-50 (1967) CA 66 52577a... [Pg.210]

Determination of Urinary Pregnane-diol, Pregnanetriol, and Pregnane-trio lone in Normal Children and Adults by Chromatography Acta Endocrinol. (Copenhagen) 62(2) 315-318 (1969) CA 71 121251g... [Pg.284]

A urinary metabolite of 17-hydroxyprogesterone, an intermediate in the biosynthesis of cortisol. Increased urinary excretion of pregnanetriol occurs in the 11-hydroxylase and 21-hydroxylase deficient forms of congenital adrenal hyperplasia, when plasma levels of 17-hydroxyprogesterone accumulate as a result of the metabolic block. [Pg.293]

See other pages where Pregnanetriol,urinary is mentioned: [Pg.27]    [Pg.549]    [Pg.575]    [Pg.583]    [Pg.495]    [Pg.510]    [Pg.510]    [Pg.510]    [Pg.2110]    [Pg.239]    [Pg.83]    [Pg.125]    [Pg.126]    [Pg.192]    [Pg.193]    [Pg.195]    [Pg.196]    [Pg.209]    [Pg.283]    [Pg.492]    [Pg.8]    [Pg.195]    [Pg.316]   
See also in sourсe #XX -- [ Pg.510 ]



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Pregnanetriols

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