Voriconazole pregnancy

Micafungin Topical 0.1% solution 1 drop ql h while awake Side effects include pulmonary edema, blood dyscrasias, hypercalcemia, hepatotoxicity (rare), gastrointestinal symptoms, headache, fever, chills, anemia, eosinophilia, hypokalemia, liver function test elevations, infusion site reactions. Drug interaction with cyclosporine and additional voriconazole. Pregnancy category C lactation safety unknown. Coadministration of caspofungin is contraindicated with multiple antiretrovirals (refer to Table 11-3) Topical not commercially available... 

Voriconazole (Vfend UK-109,495) is a triazole with a structure similar to fluconazole but has increased activity in vitro, an expanded spectrum, and poor aqueous solubility (pregnancy risk category C). 

Pregnancy A 28-year-old woman without medical history received voriconazole for invasive aspergillosis 3 months during second and third trimester [34 ]. She gave birth to a healthy boy at 35 weeks of gestation. Qose evaluations including karyotype and growth at the 6-month follow-up visit were normal. 

Shoai Tehrani M, Sicre de Fontbrune F, Roth P, AUisy C, Bougnoux ME, Hermine O, et aL Case report of exposure to voriconazole in the second and third trimesters of pregnancy. Antimicrob Agents Chemother 2013 57(2) 1094—5. 

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