Pregnancy rubella

Togaviruses Rubella Spherical particles 70 nm in diameter, a tightly adherent envelope surrounds an icosahedral capsid Causes German measles in children. An infection contracted in the early stages of pregnancy can induce severe multiple congenital abnormalities, e.g. deafness, blindness, heart disease and mental retardation... 

Rubella is a mild, often subclinical infection that is common amongst children aged between 4 and 9 years. Infection during the first trimester of pregnancy brings with it a... 

Rubella component Administer 1 dose of MMR vaccine to women whose rubella vaccination history is unreliable or who lack laboratory evidence of immunity. For women of childbearing age, regardless of birth year, routinely determine rubella immunity and oounsel women regarding congenital rubella syndrome. Women who do not have evidence of immunity should receive MMR vaccine upon completion or termination of pregnancy and before discharge from the health-care facility. 

Although the vaccine has not been associated with congenital rubella syndrome, its use in pregnancy is contraindicated. Women should be counseled not to become pregnant for 4 weeks after vaccination. 

Rubella, also known as German measles, is caused by the rubella virus. Rubella contracted during pregnancy is dangerous to the fetus, especially in the first trimester and may lead to stillbirths, congenital malformations or abortion. 

The rubella virus results in a self-limiting infection characterised by a rash spreading from the face, trunk and limbs. The infection commonly occurs in children. The rubella virus has the most serious effect on the fetus. Rubella occurring during pregnancy, especially during the first trimester, may result in spontaneous abortion, stillbirths or congenital malformations. 

Rubella soon after birth is a disease which is usually trivial and of short duration. Its most obvious sign is a mild rash. Rubella virus infection during pregnancy can disrupt fetal growth and cause birth defects. 

Continued surveillance in the USA (data collected through the Vaccine in Pregnancy Registry) has not shown evidence that RA 27/3 rubella vaccine, administered during pregnancy, can cause the congenital rubella syndrome (136). 

Centers for Disease Control (CDC). Rubella vaccination during pregnancy—United States, 1971-1986. MMWR Morb Mortal Wkly Rep 1987 36(28) 457-61. 

Bart s (y ). Mothers carrying a fetus with Hb Bart s usually present clinically between 20 and 26 weeks gestation with pregnancy-induced hypertension and polyhydramnios. Ultrasound of the fetus shows hydrops. Severe anemia (Hb usually <80g/L) is noted on a fetal blood sample obtained by cordocentesis. It is important to rule out other causes for the hydropic fetus by performing TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex) testing. 

Other preconception interventions with evidence of improving pregnancy outcomes include screening and immunization for rubella and varicella." Influenza vaccine is also recommended for women who will be in the second or third trimester during the influenza season." Pregnant women who contract influenza may have greater morbidity and mortahty owing to the risk of pneumonia."... 

Centers for Disease Control and Prevention. Revised ACIP recommendation for avoiding pregnancy after receiving a rubella-containing vaccine. 80. 

Analogy. HiU gives as an example of analogy that the effects of rubella or thalidomide should aUow us to accept slighter but similar evidence with another drug or another viral disease in pregnancy. 

As a result of your investigations, pregnancy is confirmed. Mrs A. has clearly serological evidence of childhood infection with Rubella when she attends your antenatal clinic 10 days later. List the information you require in order to make appropriate arrangements for her delivery. 

Rubella Live virus Avoid during pregnancy... 

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