Pregnancy postpartum depression

Maguire, J., and Mody, 1. (2008). GABA(A)R plasticity during pregnancy Relevance to postpartum depression. Neuron 59, 207—213. 

Gotlib, I.H., Whiffen, V.E., Mount, J.H., Milne, K., and Cordy, N.I. (1989) Prevalence rates and demographic characteristics associated with depression in pregnancy and the postpartum. / Consult Clin Psychol. 57 269-274. 

Case Example A 28-year-old woman had been stable on lithium treatment for several years. When she became pregnant, her lithium was discontinued, and within a few weeks she was hospitalized for a severe exacerbation of mania unresponsive to CPZ in doses up to 1,200 mg/day. After a course of ECT she became euthymic and was adequately maintained on lower doses of CPZ (i.e., 50 to 100 mg/day) for the remainder of her pregnancy. The delivery and the immediate postpartum period went well, but lithium was not resumed because she opted to nurse her infant. Several weeks later, she was rehospitalized for an episode of depression, which also responded to a course of ECT. She then agreed to discontinue nursing her child and resume lithium. The patient was doing well at follow-up 1 year later. 

Skouteris, H., Wertheim, E. H., Rallis, S., Milgrom, J., and Paxton, S. J. (2009). Depression and anxiety through pregnancy and the early postpartum An examination of prospective relationships. J. Affect. Disord. 113, 303—308. 

Josefsson A, Berg G, Nordin C, Sydsjo G (2001) Prevalence of depressive symptoms in late pregnancy and postpartum. Acta Obstet Gynecol Scand 80 251—255. 

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