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Pregnancy and developmental toxicology

The most sensitive toxicological effects of lasalocid were increased adrenal weight and minor changes to some blood biochemistry parameters that were seen in a two year rat feeding study, and reductions in pregnancy and fetal bodyweight in a rabbit developmental study. An NOEL of 0.5 mg/kg bw/day was identified for all these effects. The CVMP noted that published studies showed that high doses could cause peripheral neuropathy in birds, but also noted the absence of special studies of neurotoxicity in mammals. [Pg.23]

See other pages where Pregnancy and developmental toxicology is mentioned: [Pg.215]    [Pg.216]    [Pg.217]    [Pg.218]    [Pg.219]    [Pg.220]    [Pg.221]    [Pg.222]    [Pg.222]    [Pg.223]    [Pg.224]    [Pg.215]    [Pg.216]    [Pg.217]    [Pg.218]    [Pg.219]    [Pg.220]    [Pg.221]    [Pg.222]    [Pg.222]    [Pg.223]    [Pg.224]    [Pg.186]    [Pg.344]    [Pg.352]    [Pg.370]    [Pg.848]    [Pg.743]    [Pg.744]    [Pg.545]    [Pg.484]    [Pg.100]    [Pg.35]    [Pg.372]    [Pg.2223]    [Pg.156]    [Pg.191]   


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Developmental toxicology

Pregnancy and

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