Pregnancy adverse drug reactions

Allergy or history of adverse drug reactions / Age of patient / Pregnancy... 

Pregnancy and labour are also times of altered drug responsiveness the fetus has special susceptibility to some adverse drug reactions though may be immune to others, for example due to the drug not passing the placenta. 

Jacobson SJ, Jones K, Johnson K, et al. Prospective multicentre study of pregnancy outcome after lithium exposure during the first trimester. Lancet 1992 339 530-3. Campbell JPM, Howie JGR. Involving the patient in reporting adverse drug reactions. J Roy Coll Gen Pract 1988 38 370-1. 

Antithyroid drugs Noninvasive Lower initial cost Low risk of permanent hypothyroidism Possible remissions due to immune effects Low cure rate (30%-80% average 40%-50%) Adverse drug reactions Drug compliance Lirst-line treatment in children, adolescents, and in pregnancy Initial treatment in severe cases or preoperative preparation... 

Toxicity Adverse effects include gastrointestinal irritation, headache, and dark coloration of urine. More serious toxicity includes leukopenia, dizziness, and ataxia. Drag interactions with metronidazole include a disulfiram-like reaction with ethanol and potentiation of coumarin anticoagulant effects. Although it is not contraindicated in pregnancy, the drug should be used with caution. 

Adverse reactions associated with their administration include hypertension, headache, and possible seizures. Nausea, vomiting, chest pains, difficulties in breathing, and leg cramps also have been reported. These alkaloids should not be used in cases of threatened spontaneous abortion or in patients with known allergies to the drugs. Contraindications generally include angina pectoris, myocardial infarction, pregnancy, and a history of a cerebrovascular accident, transient ischemic attack, or hypertension. 

Amphotericin B is obtained from Streptomyces nodosus. It is fungistatic and administered intravenously as an infusion in the treatment of severe systemic fungal infections. It also is used for the local treatment of superficial candidiasis. Test-dose administration is advised to confirm adverse reactions. The amphotericin infusion should be slow to prevent the risk of irritation and infusion-related adverse effects. The drug is used in pregnancy without any adverse side effects.66... 

Adverse reactions No significant adverse effects or drug interactions Pregnancy Probably safe in pregnancy and lactation Relative cost S... 

The prescriber. Adverse reactions may occur because a drug is used for an inappropriately long time (type C), at a critical phase in pregnancy (type D), is abruptly discontinued (type E) or given with other drugs (interactions). 

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