Peripheral edema pregabalin

Guzelkucuk U, Duman I, Yilmaz B, Tan AK. Reversible post-pregabalin peripheral edema in a spinal cord injury patient. Spinal Cord June 2012 50(6) 472. ... 

Pregabalin is another second-generation anticonvulsant that has recently obtained FDA approval for treatment of neurogenic pain, and several randomized placebo controlled studies have shown that this compound is efficacious in the treatment of painful diabetic neuropathy [32]. Doses between 300 and 600 mg/day have shown effect already apparent after 1 week of treatment. There are few clinically important drug interactions as there is no interference with the cytochrome 450 system. This compound requires minimal dose titration and seems easy to use. Side effects to gabapentin and pregabalin include drowsiness, dizziness and peripheral edema. 

Peripheral edema, which occurred in 6% of patients administered pregabalin in controlled trials (compared to 2% in the placebo arm). The peripheral edema is not a consequence of congestive heart failure, or renal or hepatic insufficiency. The thiazolidinedione class of oral hypoglycemics may increase the risk of fluid retention. In addition, because of limited data, pregabalin should be administered cautiously in patients with NYHA class III or IV cardiac status. 

Observational studies In 15 patients with familial dysautonomia, pregabalin up to a dose of 6 mg/kg/day gave good results in the treatment of nausea and dysautonomic crises [261 ]. Adverse effects included peripheral edema in one patient who... 

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