Neurogenic pain

Unlabeled Uses Treatment of alcohol withdrawal, diabetes insipidus, neurogenic pain, psychotic disorders... 

Unlabeled Uses Treatment of bulimia nervosa, cataplexy associated with narcolepsy, depression, neurogenic pain, panic disorder, ejaculatory disorders, pervasive developmental disorder... 

I Unlabeled Uses Treatment of neurogenic pain, panic disorder prevention of vascular headache, pruritus in idiopathic urticaria... 

It is indicated in neurotic, reactive, masked endogenous, recurrent depression depression with insomnia, depression, enuresis, panic disorder, neurogenic pain, urticaria and nausea and vomiting during chemotherapy maniac depressive psychosis in depressive phase. 

SSR240612 is a new, potent, and orally active selective antagonist of Bi receptors in humans and several animal species. It exhibits analgesic and anti-inflammatory activities in mice and rats and is currently in preclinical development for the treatment of inflammatory and neurogenic pain. 

Neurogenic pain is seen in approximately 10% of all diabetic patients, and is associated with substantial impairment in QOL. Except for optimization of meta-bohc control and a-Unoic acid none of the above pathogeneticaUy directed treatments have shown long-term clinical effect. Accordingly, various symptomatic treatments have been tested. These are all without any effect on the underlying disease process. 

Pregabalin is another second-generation anticonvulsant that has recently obtained FDA approval for treatment of neurogenic pain, and several randomized placebo controlled studies have shown that this compound is efficacious in the treatment of painful diabetic neuropathy [32]. Doses between 300 and 600 mg/day have shown effect already apparent after 1 week of treatment. There are few clinically important drug interactions as there is no interference with the cytochrome 450 system. This compound requires minimal dose titration and seems easy to use. Side effects to gabapentin and pregabalin include drowsiness, dizziness and peripheral edema. 

Long-term use of opioids in diabetic patients remains controversial and many find the neurogenic pain to be insensitive to opioids and not be used due to the risk of abuse. Tramadol is a weak opioid with inhibitory effects on reuptake of serotonin and norepinephrine as well. Tramadol... 

Indications Psychoses involving hallucinations, agitation, manic phase of bipolar psychoses nausea and vomiting induced by CNS dysfunctions anxiety severe behavioral problems, abdominal pain associated with porphyria, delirium, neurogenic pain Common drug examples ... 

Small studies have shown moderate benefit in the treatment of post-herpetic neuralgia and post-stroke pain. Treatment of other neurogenic pain syndromes with carbamazepine is considered a non-FDA-labeled indication. 

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