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Preformed vesicle approach

Entrapment of Polynucleotides Using the Preformed Vesicle Approach... [Pg.132]

In summary, the preformed vesicle approach and detergent dialysis procedure have enabled development of nucleic acid-based therapeutics with clinical utility. Further applications of these liposomal systems with new nucleic acid-based therapeutics such as small interfering RNA for gene silencing are being developed and have demonstrated promising results (28). [Pg.146]

The preformed vesicle (PFV) approach involves incubation of liposomes containing a cationic lipid and a PEG coating with polynucleotides in the presence of ethanol. Typically, LUV composed of distearoyl-phosphatidyl-choline (DSPC), cholesterol (Choi), l-0-(2 -(oi-methoxy-polyethylene-glycol)... [Pg.132]

See other pages where Preformed vesicle approach is mentioned: [Pg.132]    [Pg.135]    [Pg.141]    [Pg.144]    [Pg.132]    [Pg.135]    [Pg.141]    [Pg.144]    [Pg.116]    [Pg.123]    [Pg.209]    [Pg.249]    [Pg.11]   


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Preformation

Preforming

Preforms

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