Prednisolone sodium succinate

C21H2SO5 50-24-8) see Loteprednol etabonate Prednicarbate Prednimustine Prednisolamate, Prednisolone sodium phosphate Prednisolone sodium succinate Prednisolone sodium sulfobenzoate Prednisolone steaglate Prednisolone tebutate Prednisolone 21-trimethylacetate ... 

One interesting feature of stability is that a product may have two shelf lives, one for the manufactured material and another for the reconstituted or opened pack. Methyl prednisolone sodium succinate lyophihsed injection, for example, is stable for up to 3 years in the dry state but the reconstituted injection must be used within 12 h. 

The mineralocorticosteroid activity of methyl-prednisolone is even less than that of prednisone/ prednisolone. It has a comparable duration of action. It is less suitable for substitution therapy in patients with adrenal hypofunctional states. Methyl-prednisolone sodium succinate is formulated for parental administration while methylprednisolone acetate is used for intra-articularly or peri-articularly injections. It can also be administered IM and then has prolonged systemic effects, lasting 1 weeks as the acetate is absorbed slowly from the site of injection. Oral absorption is rapid with peak effects within 1-2 hours. The duration of action is then about 1.5 days. 

Prednisolone sodium succinate lOmg/L Sodium carbonate, sodium hydrogen phosphate, 915.6 182.3... 

C2,H,2Ok 2920-86-7) see Prednisolone sodium succinate 4-[[(2-carboxyphenyl (carbonyl ]amino ]-/V-(aminocarbo-nyl)benzenesulfonam ide (C 5H iN,OfiS) see Sulfaloxic acid carbromal... 

Methyl prednisolone sodium succinate has been proposed in the following regime ... 

The plasma half-life of prednisolone following the oral administration of prednisone to normal subjects ranges form 2.5 to 3.5 h (126, 130, 131). Similar half-life values for prednisolone were observed after oral prednisolone is administered (126, 132, 133, 134). Nugent et al (135) found after an intravenous dose of 1 mg/kg body weight of prednisolone (sodium succinate salt) an average half-life of 3.5 h. After an intravenous dose of 0.3 mg/kg prednisolone as phosphate the mean plasma... 

A 9-year-old boy with acute bronchopneumonia developed throat itchiness, chest stuffiness, cyanosis of the face and around the mouth, and a weak pulse 30 seconds into an intravenous infusion of Xixinnao injection 8 mg in 100 ml 5% dextrose. The infusion was stopped immediately. He gradually recovered over 3 hours after receiving oxygen and methyl-prednisolone sodium succinate. 

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