Predictive Modeling Approaches for Assessing Human Lead Exposure

Predictive Modeling Approaches for Assessing Human Lead Exposure 

What are models, and specifically exposure models Mushak (1989) offered a broad definition for models as being  

Confined to lead exposure model conceptualization, such models are con-stmctions and depictions specifically intended to set forth toxicokinetic, biological, and toxicological grounds for the multiple sequenced relationships that link a potential lead source to a quantitative statement of lead s presence 

Predictive Pb exposure models serve various pmposes in lead environmental epidemiology and human lead risk assessments. For example, weU-validated mechanistic, i.e., biokinetic, models can generate outputs that substitute for measurement data where gathering measurements may not be feasible or even possible. These constraints arise from realities of resource limits, poor subject accessibility, or inappropriate timing for gathering the 

Trace Metals and other Contaminants in the laivironment, Vcriume 10 

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