Predictive Attempts Based on Inserting CDR Sequences upon a Constant Framework

Predictive Attempts Based on Inserting CDR Sequences upon a Constant Framework 

Stereodrawings of the a-carbon skeletons of the V-regions of the four proteins studied crystallographically. Each protein is in the same orientation. (Other views and coordinates used in Figs. 12, 13, and 14 may be found in Feldman, 1977). With a stereo viewer it is possible to see two adjacent models at the same time, so that a comparison may be made in three dimensions. 

Sterodrawings of the a-carbon skeletons of the three CDR of the four VL regions studied crystallographically. Note in Newm that the second CDR is much farther from the other two CDR than it is in the other three chains. This is due to a deletion (see text). 

Stereodrawings of the a-carbon skeletons of the three CDR of the two heavy chains studied crystallographically. 

Similarities in the gross orientation of the CDR of two Fab structures, Newm and MOPC 315, were evident (Poljak et al., 1975), and a detailed effort to build the backbone of the site for MOPC 315 has re- 

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