CDR sequences

Soderlind, E., Strandberg, L., Jirholt, P., et al. (2000). Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries. Nat. Biotechnol., 18, 852-856. 

IX. Predictive Attempts Based on Inserting CDR Sequences upon a Constant... 

Fig. 15. Stereomodels of the predicted MOPC 315 site. (A) Constructed from its sequence and inserting the CDR sequences into the framework of McPC 603 (Padlan et al., 1976a). (B) Revised model with incorporation of data from nuclear magnetic reso-nence and spin-labeled haptens (Dwek et al., 1977).

Immunomodulatory, Immunosupressant. Humanized IgGl Mab that binds to the human IL-2R (anti-CD25). Composite of 90% human (IgGl constant plus variable framework regions of the Eu myeloma Ab) and 10% murine Ab (CDR) sequences. 

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