Preclinical drug development overview

OVERVIEW OF IN VITRO SKIN MODELS WITH RELEVANCE TO PRECLINICAL DRUG DEVELOPMENT... 

A number of excellent review articles exist, including several that explain MR spectroscopy and detail the impact of MR spectroscopy in drug design and in preclinical studies, and others that provide overviews of human in vivo metabolism and pharmacokinetics measured by 19F MR in fluoropyrimidine compounds as well as in psychotropic compounds [1, 3-5, 7-10, 59, 60-63], In keeping with other facets of drug development, the number of 19F MR clinical investigations is much smaller than the number of animal model, specimen, cell line, or solution experiments. 

FIGURE 2.3 An overview of the drug development process that illustrates the activities within the four major stages of drug development drug discovery, preclinical development, clinical development, and manufacturing. (Courtesy of Milestone Development Services, Newtown, PA, 1998. With permission.)... 

Overview of Safety Evaluation and Quantitative Approaches during Preclinical and Early Phases of Drug Development... 

Among the several drug delivery systems, liposomes - phospholipid nanosized vesicles with a bilayered membrane structure - have drawn a lot of interest as advanced and versatile pharmaceutical carriers for both low and high molecular weight pharmaceuticals. At present, liposomal formulations span multiple areas, from clinical application of the liposomal drugs to the development of various multifunctional liposomal systems to be used in therapy and diagnostics. This chapter provides a brief overview of various liposomal products currently under development at experimental and preclinical level. 

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