Precision Amphiphilic Copolymers

Figure 10.12 Synthetic route a variety of precision amphiphilic copolymers. (Reprinted from E.B. Berda and K.B. Wagener, ADMET polycondensation of diketopiperazine-based dienes. Polymerization behavior and effect of diketopiperazine on the properties of the formed polymers, Macromolecular Chemistry and Physics, 209, 1601-1611 2008, with the permission of John Wiley Sons, Inc.)...

To evaluate the affect interactions of the pendant branches could have on the behavior of these precision amphiphilic copolymers a family of similar polymers with hydroxy-terminated PEG... 

Figure 10.13 Thermal behavior of precision amphiphilic copolymers featuring precise placement of methoxy terminated PEG branches.

Figure 10.14 Thermal behavior and scattering data of precision amphiphilic copolymers featuring precisely placed hydroxy terminated PEG branches. (Reprinted with permission from E.B. Berda, R.E. Lande and K.B. Wagener, Precisely defined amphiphilic graft copolymers, Macromolecules, 40, 8547-8552, 2007. 2007 American Chemical Society.)...

The use of an amphiphilic copolymer as a surfactant allows for an increase of the lifetime of multiple emulsions. The structural properties emulsions should thus be precisely studied. We performed direct confocal naicroscopy observations as well as light-scattering experiments in order to investigate the dynamics of the inverse droplets inside oil globules. Depending on the emulsion formulation, we showed that droplets are either unifomaly distributed inside direct globules, or they are depleted toward the inner surface of the globules. These structural differences appear to play a key role in the destabilization and release processes. 

These calculations are a first step towards the prediction of the phase behavior of the three-component system water, ethanol and amphiphilic block copolymer. Hopefully, results based on this modeling approach can lead to a simplified synthesis and more precise tailoring of the structural features in meso-ordered thin films. 

An amphiphilic block copolymer with a precisely hydrophilic/hydrophobic balance can form a core-shell micelle structure in an aqueous solution. The hydrophobic inner core can encapsulate the hydrophobic drugs and the high drug-loading capacity has been applied to an excellent drug carrier (Fig. 2.1.2) [36-38]. Kataoka et al. have reported various... 

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