Pre-B-cell colony-enhancing factor

Pre-B cell colony-enhancing factor lL-8 Downregnlated genes myeloid cell nuclear differentiation antigen heavy chain moesin MIP-2 myeloid cell nuclear differentiation antigen... 

S.2.2.2 Salvage Pathway from Nicotinamide. Although an activity that converted nicotinamide to NAD independently of nicotinic acid had been indicated for some time, the enzyme was not identified until recently (Rongvaux et al. 2002). Nicotinamide is coupled directly to phosphorybosyl pyrophosphate to form nicotinamide mononucleotide by nicotinamide phos-phoribosyltransferase, an enzyme that was previously identified as a cytokine pre-B-cell colony-enhancing factor (PBEF) and controversially claimed as an insulin-mimetic hormone visfatin (Imai 2009) (Figure 7.2). 

Rongvaux, A., Shea, R.J., Mulks, M.H., Gigot, D., Urbain, J., Leo, O., and Andris, F., 2002. Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. European Journal of Immunology. 32 3225-3234. 

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