Prazosin Digoxin

Drugs or pharmacological interventions (heparin (Berger and Zaret 1984), antimicrobials or antibiotics, anticonvulsants, tranquilizers, anti-inflammatory agents (Chervu et al. 1981 Hladik et al. 1982), nifedipine (Sampson 1993), prazosin, digoxin (Lee 1983), propanolol, hydralazine, methyldopa, verapamil, chlorothiazide, furosemide, ranitidine, iron therapy, etoposide-h doxontbicin (Sampson 1993, 1995), others)... 

ALPHA-BLOCKERS CARDIAC GLYCOSIDES Possibility of T plasma concentrations of digoxin no cases of toxicity have been reported with doxazosin or prazosin Doxazosin inhibits P-gp-mediated elimination of digoxin mechanism with prazosin is uncertain at present Monitor digoxin levels... 

Noninterfering albuterol, allopurinol, alprenolol, aspirin, atenolol, captopril, carbimazole, clonidine, coloxyl, danthron, diazepam, digoxin, doxepin, glibenclamide, hydralazine, in-domethacin, labetalol, metformin, methyldopa, metoprolol, mianserin, minoxidil, nifedipine, nitrazepam, oxazepam, oxprenolol, pindolol, prazosin, propranolol, senokot, theophylline, trifluoperazine... 

Svirbely, J.E. Pesce, A.J. TWmethoprim analysis by LC. J.Liq.Chromatogr., 1988,11, 1075—1085 [LOD 50 ng/mL serum plasma dialysate urine CSF SPE interfering atenolol, procainamide, oxazepam non-interfering acetaminophen, amitriptyline, ampicillin, caffeine, cefitoxin, chlordiazepoxide, chlorpheniramine, chlorpromazine, cimetidine, clonidine, desipramine, diazepam, digoxin, diphenhydramine, doxepin, doxylamine, erythromycin, flurazepam, imipramine, lidocEune, minoxidil, nadolol, nortriptyline, prazosin, propranolol, quinidine, theophylline, thioridazine]... 

PO/IV. Well absorbed, 80% metabolized in first pass. 90% protein bound. Metabolites are active. Half-life is 5 hrs but may be up to 20 hrs in patients with cirrhosis. Patient on IV blockers or digitalis. A-V node block, sick sinus syndrome, cardiogenic shock, heart failure, hypotension. Beta blockers or digitalis Increases likelihood of bradycardia or A-V blockade. Quinicfine or prazosin Increases hypotension. Digoxin levels are increased. Cimetidine reduces verapamil clearance. Calcium supplements may inhibit actions of verapamil. Depolarization (leading to contraction) of vascular smooth muscle is dependent on calcium entry. Vasodilation is induced by calcium entry blockers because they inhibit calcium influx. 

A rapid and marked rise in serum digoxin levels occurred in one study when prazosin was also given. Alfuzosin, doxazosin, tamsu-losin and terazosin appear not to interact with digoxin. 

Copur S, Tokgozoglu L, Oto A, Oram E, Ugurlu . Effects of oral prazosin on total plasma digoxin levels. Fundam Clin Pharmacol (1988) 2,13-17. 

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