PPAR-interacting protein

Guo, D., Sarkar, J., Ahmed, M.R., Viswakarma, N., Jia, Y., Yu, S., Sambasiva Rao, M. and Reddy, J.K. (2006) Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver. Biochemical and Biophysical Research Communications, 347, 485—495. 

A. Mechanism and Effects Fibric acid derivatives (eg, gemfibrozil, fenofibrate, clofibrate) are ligands for the peroxisome proliferator-activated receptor-alpha (PPAR-a) protein, a receptor that regulates transcription of genes involved in lipid metabolism. Tbis interaction with PPAR-a results in increased activity of lipoprotein lipase and enhanced clearance of triglyceride-rich lipoproteins (Figure 35-2). Cholesterol biosynthesis in the liver is seeondarily reduced. The fibrates reduce serum triglyceride concentrations (Table 35-3). There may be a small reduction in LDL cholesterol and a small increase in HDL levels. 

Fig. 1.29 Interactions of EPA with PPAR-. (a) The carboxylate head group of the ligand interacts with three protein residues, His-323, His-449 and Tyr-473. (b) Two distinct confor-...

---