Potential Biomarkers Related to Pituitary Adenomas

Discovery of potential biomarkers related to pituitary adenomas 

Pituitary hormone isoforms in human pituitary adenomas 

Protein isoforms result from protein PTMs, splicing, etc. Our comparative proteomics study of human pituitary adenomas demonstrated that human pituitary hormones had multiple isoforms. The change of a neuroendocrine hormone level is an important clinical feature in a human pituitary adenoma. Not all of the isoforms are related to pituitary adenomas [32]. 

Therefore, our detailed study of the different isoforms and PTMs of GH and prolactin could lead to new insights into the clinical importance of pituitary hormones in the formation of a pituitary adenoma (see Section 2). The ratio of the change of each isoform in human pituitary tissue has value for clinical research. 

For example, could a change in the ratios of the prolactin isoforms be a potential index for diagnostics and prognostics of a prolactinoma patient Could an alteration of circulating GH isoforms be a potential index for diagnostics and prognostics of a GH adenoma patient  

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