Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Posttranslational modifications screening

With the development of an atmospheric-pressure ionization (API) source, coupling of LC with MS has become a routine matter. The ESI format of API is the most appropriate interface for the LCYMS combination because (1) of its potential for the analysis of a variety of nonvolatile and thermally labile molecules of low to very high molecular mass at unprecedented low detection sensitivity, (2) ionization occurs at atmospheric pressure, (3) of its compatibility with RP-LC solvents, and (4) a range of solvent flow can be accepted. As a consequence, the LC/ESI-MS combination has gained prominence in several areas of research, such as to sequence proteins to identify mixtures of compounds, tryptic maps, and posttranslational modifications in proteins to elucidate structure of metabolic products to analyze drugs, pesticides, and toxins and to screen combinatorial libraries. The development of LC/ESI-MS has also greatly advanced the science of quantification. Several reviews of LC/ESI-MS technology have appeared in the literature [37-40]. [Pg.168]

See other pages where Posttranslational modifications screening is mentioned: [Pg.44]    [Pg.201]    [Pg.99]    [Pg.100]    [Pg.6]    [Pg.367]    [Pg.13]    [Pg.164]    [Pg.241]    [Pg.203]    [Pg.143]    [Pg.318]    [Pg.59]    [Pg.99]    [Pg.2214]    [Pg.415]    [Pg.544]    [Pg.547]    [Pg.364]    [Pg.9]    [Pg.14]    [Pg.537]    [Pg.313]    [Pg.337]    [Pg.345]    [Pg.470]    [Pg.1132]    [Pg.86]    [Pg.210]    [Pg.83]    [Pg.2894]    [Pg.485]    [Pg.374]    [Pg.164]    [Pg.100]   
See also in sourсe #XX -- [ Pg.22 , Pg.23 ]



SEARCH



Posttranslation modification

Posttranslational

Posttranslational modification

© 2024 chempedia.info