Postpartum hemorrhage treatment

Pelage JP, Soyer P, Repiquet D, et al. (1999) Secondary postpartum hemorrhage treatment with selective arterial embolization. Radiology 212 385-389... 

Pelage JP, Le Dref O, Mateo J et al. (1998) Life-threatening primary postpartum hemorrhage treatment with emergency selective arterial embolization. Radiology 208 359-362... 

Ergonovine (100, R = NHCH(CH3)CH2 0H) was found to yield lysergic acid (100, R = OH) and (+)-2-aminopropanol on alkaline hydrolysis during the early analysis of its stmcture (66) and these two components can be recombined to regenerate the alkaloid. Salts of ergonovine with, for example, malic acid are apparently the dmgs of choice in the control and treatment of postpartum hemorrhage. 

Misoprostol may also prove useful in the treatment of postpartum hemorrhage and has also been used in organ transplantation. For example, it has been reported to improve kidney function in cyclosporin-treated patients who have received renal transplants (334). 

Significant side effects are those associated with its abortifacient properties and other smooth muscle contraction effects, e.g., diarrhea and abdominal pain. Misoprostol also is an effective cervical ripening agent (by vaginal application) for the induction of labor. Other unlabeled uses include the treatment of postpartum hemorrhage and, with mifepristone, termination of pregnancy. 

Ergonovine is a water-soluble lysergic acid derivative that occurs in ergot. It is used as an oxytocic agent. Its maleate derivative is used in the treatment of postpartum hemorrhage. 

This compound is a homologue of ergonovine. It is used in the treatment of postpartum hemorrhage. 

The dried fruits of Tetradium (Euodia) rutaecarpa have long been used in Chinese medicine for the treatment of headaches, abdominal pain, dysentery, postpartum hemorrhage, and amenorrhea (Bergman, 1983). The alkaloids from these fruits have marked uterotonic effects (King et al., 1980). 

Bees have been used therapeutically in some animal populations for treatment of a variety of disorders. A recent study examined the effects of bee stings on sows with hypogalactia syndrome postpartum. Complications expected from this type of therapy are primarily local effects as well as more systemic hemorrhagic effects. 

Ergonovine is a uterine stimulant that increases strength, duration, and frequency of uterine contractions and decreases uterine bleeding. It is indicated in prevention and treatment of postpartum and postabortal hemorrhage caused by uterine atony. 

Uterine artery embolization (UAE) is an established technique that has been used to stop life-threatening vaginal hemorrhage in women with malignancy, postpartum uterine atony, or traumatic injury since the mid-1970s [8,18,52,64,112]. The first successful treatment of symptomatic fibroids of the uterus by UAE was reported by Ravina et al. in 1994 [150]. 

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