Post-polio syndrome

Fatigue accompanies viral infection, sepsis, trauma or major surgery. The cause of this fatigue is not known it may be peripheral, central or both. Studies on biopsy samples of patients with trauma show a reduction in the muscle ATP concentration, which could be responsible for peripheral fatigue, as explained above (Chapter 18 Table 13.3). Central fatigue has been identified in three different clinical conditions, post-polio syndrome, multiple sclerosis and after spinal cord injury, but has not been investigated in other conditions. 

Miller, B. C. (1994, June 6). Post-polio syndrome in mountain communities. The Journal of Modern Medicine, 86, 1299-1302. Retrieved April 1995, from DIALOG database ( 321, Modern Medicine) on the World Wide Web http// www.dialogweb.com... 

Perry, J., Muhoy, S.J., and Renwick, S.E., The relationship of lower extremity strength and gait parameters in patients with post-polio syndrome. Arch. Phys. Med. Rehabil, 74,165,1993. 

Parissis D, Karkavelas G, Taskos N, Milonas I. (2003) Inclusion body myositis in a patient with a presumed diagnosis of post-polio syndrome. J Neurol 250(5), 619-621. 

Some neuromuscular diseases, for example Guillain-Barre syndrome, may only require temporary ventilatory support (8) while others, such as post-polio syndrome require lifelong noninvasive ventilatory support (9). Amyotrophic lateral sclerosis (ALS) is a... 

Acute paralytic poliomyelitis is still endemic in some countries and vaccine-associated poliomyelitis continues to occur (125). After many years of stability, some patients do deteriorate (126). This post-polio syndrome may be characterized by the development of progressive weakness associated with respiratory symptoms among those ventilated during their acute illness (127). Respiratory failure results from thoracic restriction as well as muscle weakness and bulbar involvement (128). Tracheostomy can be avoided with continuous NIV and aggressive mechanical in-exsufflation (128). Retrospective studies of NIV have reported survival rates >90% at five years, making this group the one with the highest benefit (76,129). 

Stuifbergena AK, Seraphineb A (2005) Tracie Harrisona, Eishi Adachi, An explanatory model of health promotion and quality of life for persons with post-polio syndrome. Social Science Medicine, 60, pp. 383-393. 

Figure 3 Percentage of users in each disease category by country. The symbol represents lung/ airways (COPD, cystic fibrosis, bronchiectasis, pulmonary fibrosis, and pediatric diseases) , chest wall deformities (kyphoscoliosis, old TB, OHS, surgical resection) and , neuromuscular disorders (muscular dystrophy, motor neuron disease, post-polio kyphoscoliosis, central hypoventilation, spinal cord damage, and phrenic nerve palsy). Abbreviations COPD, chronic obstructive pulmonary disease TB, tuberculosis OHS, obesity hypoventilation syndrome. Source From Ref. 15.

The aim of this present study was to develop a patient specific 3D musculoskeletal model of the Post Polio Residual Paralysis (PPRP) subject. This model will allow the effects of the lower limb orthosis on the gait kinematics and kinetics of the patient with PPRP syndrome to be quantified objectively. A healthy 3D musculoskeletal model was also developed as a reference model to pick out pathological disorders of post-polio subject... 

---