Post antibiotic effect

Rokitamycin is a semisjmthetic 16-membered ring macro-Ude. It is more hydrophobic, and has better bacterial uptake and slower release, more cohesive ribosomal binding, and a longer post-antibiotic effect than other 14-, 15-and 16-membered ring macroUdes (1). 

Although not performed routinely during the clinical man- agement of patients with infections, data from certain laboratory tests (e.g., minimal bactericidal concentration tests, timed-kill tests, post-antibiotic-effect tests, and antimicrobial combination testing) are important for the clinician to understand because they help to determine an antimicrobial s pharmacodynamic properties. 

Antibacterial effects depend mainly on peak drug level (rather than time) and continue with blood levels < MIC-a post-antibiotic effect (PAE). 

Dubois, J., and St. Pierre, C. (2000). Intracellular activity and post-antibiotic effect of ABT-773 against Legionella. Presented at 5th ICMAS-KO (Jan. 26-28, Seville). Poster No. 02.33. 

PAE stands for post antibiotic effect This is a measure of the continued destruction of bacteria after the drug has been withdrawn. 

After the MIC has been determined, it is necessary to decide whether the results suggest whether the organisms are susceptible to the tested antimicrobial in vivo. This decision requires an understanding of the PK of the dmg (see Chapter 2 for discussion) and other factors. For example, in vitro assessments of activity may underestimate the in vivo activity because of a post-antibiotic effect and post-antibiotic leukocyte enhancement. The post-antibiotic ejfect (PAE) refers to a persistent antibacterial effect at subinhibitory concentrations, whereas the term post-antibiotic leukocyte enhancement term (PALE) refers to the increased susceptibility to phagocytosis and intracellular killing demonstrated by bacteria following exposure to an antimicrobial agent. ... 

Hanberger H, Nilsson LE, Mallei R, Isaksson B. Pharmacodynamics of daptomycin and van-comycin on Enterococcus faecaUs and Staphylococcus aureus demonstrated by studies of initial killing and post antibiotic effect and influence of Ca and albumin on these drugs. Antimi-cTob Agent Chemothei 1991 35 1710-1716. 

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