Possible Mechanisms of Neural Injury Caused by Glutamate and Its Receptors

Possible Mechanisms of Neural Injury Caused by Glutamate and Its Receptors 

Ca2+ influx mediates excitotoxicity with a cascade of events involving free radical generation, mitochondrial dysfunction, and the activation of many enzymes (Table 7.1), including those involved in the generation and metabolism of arachi-donic acid (Farooqui and Horrocks, 1991,1994b Farooqui et al., 2001 Wang et al., 

Neural injury mediated by glutamate involves two important components neu-roinllammation, a neuroprotective mechanism whose prolonged presence is injurious to neurons, and oxidative stress, cytotoxic consequences produced by oxy- 

Free radicals and lipid peroxides Increased (Wang et al., 2005) 

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