Porfimer sodium

Various antineoplastics altretamine amsacrine 1-asparaginase dacarbazine melanoma theraccine porfimer sodium procarbazine hydrochloride topotecan hydrochloride tretinoin (dil-trans retinoic acid), systemic... 

Amemiya 7 Nakajima H, Katoh 7 et al. Photodynamic therapy of atherosclerosis using YAG-OPO laser and porfimer sodium, and comparison with using argon-dye laser. Jpn Circ J I 999 63(4) 288-295. 

Chemical Name Photofrin porfimer sodium (porfimer sodium disigned also as polyporphin oligomer containing ester and ether linkage)... 

Sanofi Winthrop Pharmaceuticals, Photofrin (porfimer sodium) for Injection, Package Insert, May 1996. 

Photodynamic therapy using porfimer sodium is indicated for palliation of symptoms in patients with completely or partially obstructing esophageal cancer or micruinvasive. small cell lung cancer. Adverse reactions include ocular sensitivity. chest pain, and respiratory distress. 

Polythia/ide. 605-6)0. 6O61. 6OK1. 620 Pundimin. See Penflurainine hydrochloride Hinsiel. See Mefenomic acid Porfimer sodium. 430.433 Purfirom>vtn. 419 Porlamincs. 83.3t... 

Photofrin ir porfimer sodium, phthalofyne rtalofyne. phthalylsulfathiazole phthalylsulphathiazole. phthalylsuiphathiazole [ban] (phthalylsulfathiazole... 

Early studies with PDT employed complex mixtures of poorly defined porphyrins known as hemato-porphyrin derivative (photofrin I) or a partially purified mixture known as porfimer sodium (PHOTOFRIN II) that was administered parenterally with subsequent irradiation using polychromatic light sources. The major problem with this approach was the prolonged period (4-6 weeks) of photosensitivity caused by skin retention of the porphyrin formulations. This led to a search for compounds that could be administered topically and that were eliminated more readily from the skin. The porphyrin precursor S-aminolevulinic acid (ALA) is converted to various porphyrins, particularly protoporphyrin (proto), in tissues including the skin (see below). Protoporphyrin subsequently is eliminated rapidly from the body, thereby minimizing the period of skin photosensitivity to a few hours. Topically applied ALA HCl (20% wA>) and, more recently, the methyl ester of ALA have been used successfully for the PDT of various types of nonmelanoma skin cancers and premalignant lesions. 

In several patients successful treatment of BD with porfimer sodium and an argon-PDL has been described [58,80,81] (Table 5). BD also showed a good initial response to PDT with topical ALA, but long-term results varied considerably (CR 30-100%) (Table 6) [4,6,69,80]. Even repeated PDT treatments yielded a CR of only 50-75% [6,8]. The incomplete response of BD may be due to the thickened epithelial layer with reduced ALA penetration [4,5,8,58,60,63,69,71,80-83]. Complete clearance was achieved in one patient with Bowen s disease of the penis using ALA 20% + EDTA 2% + DMSO 2% and VersaLight [76]. 

Carcinoma in situ (CIS) Photoradiation was performed in 56 patients (39 CIS and 17 dysplasia) 48 h after intravenous injection of 1.5-2 mg kg of the photosensitizer Porfimer sodium (Photofrin). Complete response was reported in 54 (96.4%) of these patients [43]. 

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