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Population based genetic association studies

Genetic association studies may be either family based, or population based (26,27). Family based studies can use transmission disequilibrium tests (TDT), a test that detects association in the presence of linkage. Population-based tests use analysis of variance (ANOVA) among multiple subgroups. The TDT was first proposed by Spielman and Ewens (28). The basic premise of the TDT is that certain alleles at a locus are disproportionately transmitted Irom parents to an affected offspring therefore the basic sampling unit for the TDT is a nuclear family with at least one affected offspring... [Pg.26]

Devlin, B., et al., "Unbiased Methods for Population-Based Association Studies," Genet. Epidemiol., 21, 273-284 (2001). [Pg.70]

Satagopan JM, Elston RC. Optimal two-stage genotyping in population-based association studies. Genetic Epidemiology 2003 25 149—157. [Pg.370]

Devlin, B. Roeder, K. Bacanu, S.A. Unbiased methods for population-based association studies. Genet. Epidemiol. 2001, 21, 273-284. [Pg.1903]

Parks CG, Pandey JP, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, Feghali-Bostwick CA, Cooper GS (2004b) Genetic polymorphism in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic lupus erythematosus associations and interaction with the interleukin-1 alpha-889 C/T polymorphism. Hum Immunol, 65 622-631. [Pg.300]

Admixture mapping An association approach based on the study of admixed samples where the objective is to identify regions that tend to have genetic material fix>m one ancestral population among the diseases individuals. [Pg.307]

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Association study

Base studies

Genetic association

Genetic population

Genetics association

Population genetics

Population genetics studies

Population-based

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