Polystyrene resins chloromethyl

Hydroxyethylene resin HMPA resin Chloromethyl resin Hydroxymethyl resin Tritylchloride resin Rink amide resin Wang resin REM resin Aminomethyl resin Chloromethyl resin Wang resin Rink amide resin PAL amide resin MBHA resin Chloromethyl resin Chlorotrityl resin Wang resin PAM resin Polystyrene resin Chloromethyl resin Chlorotrityl resin Wang resin Rink amide resin Sasrin resin Polystyrene resin Chloromethyl resin Benzoic acid resin Wang resin Trityl resin 2-Chlorotrityl resin PAL resin Rink amide resin MBHA resin REM resin Hydroxymethyl resin Polystyrene Aminomethyl resin Chloromethyl resin 2-Chlorotrityl resin Hydroxyethyl resin Rink amide resin Wang resin MBHA resin Sieber resin... 

A typical system is a chlorome thy late d polystyrene resin cross-linked with 2 or 4% p-divinylbenzene and different amounts of chloromethylated sites (0.7—3.7 mequiv. of Cl per g of polymer) . The reaction is shown schematically in Eq. (6.19) and additional information may be found in Sects. 8.3 and 8.8. 

The chloromethylated polystyrene resin used for Merrifteld solid-phase peptide synthesis is prepared by treatment of polystyrene with chloromethyl methyl ether and a Lewis acid catalyst. Propose a mechanism for the reaction. 

In the case of the benzyloxytrityl-hydroxylamineresin 24b, the starting material is the Merrifield resin, chloromethylated polystyrene (1.7 mmol Cl x g 1) which is treated with 3 equiv. of 4-hydroxy-methyl benzoate in DMA with sodium methylate as base. The Beilstein test is used for monitoring and microanalyses showed the absence of chloride (Scheme 6). 

Spoly(vinylbenzylchloride). -Cross-linked using divinylbenzene. Chloromethylated, cross-linked polystyrene resins were obtained coiranercielly from Bio-Rad Laboratories. Percent chloromethylation js based on the available phenyl groups in the polymer that is minus the percent cross-linking. =D=dioxane E ethanol. Percent of available chloromethyl croups reacted with donor. —Percent reaction x percent chloromethylation. Polymer prepared by free-radical polymerization of 60.00 para-neta chloromethylated sytrene (Dow Chemical). Reaction heated at 50-55°C. 

Smith and Liu have successfully prepared an unsymmetrical analog of a Katsui-type salen ligand possessing a hydroxyalkyl group in the 6-position, which facilitated the formation of an ester Hnkage to a polystyrene carboxyl chloride resin (Figure 5.19) derived from Merrifield s resin (chloromethylated polystyrene,... 

The synthesis of (S)-zearalenone began with creation of the chlo-rodibutylstannyl polystyrene resin 32, which ultimately would serve as a Stille coupling partner. Oxidation of chloromethyl polystyrene resin fol-... 

Various thiamine derivatives were prepared on polymer support and were tested in C-C coupling reactions.40 The most straightforward approach was the alkylation of substituted 1,3-thiazoles with chloromethyl polystyrene resin yielding supported thiazolium chloride salts. Alternatively, resin-supported thiamine derivatives were constructed in a two-step process by alkylation of the primary alcohol with chloromethyl polystyrene followed by alkylation of the ring nitrogen yielding resin 12 (Fig. 8). Not only does this pathway introduce a spacer between the active thiamine... 

Hydroformylation Tristipheny 1-Rhodium (I) Chloride Chloromethylated polystyrene-resin reacted with chloro-diphenylphosphine 118... 

We are interested in the application of polymers as adsorbents, ion exchangers, fuel cells, and permeable materials. In this regard, the first resins with some of these properties were obtained by D Aleleio in 1944 based on the copolymerization of styrene and divinylbenzene. Unfunctionalized polystyrene resins cross-linked with divinylbenzene (Amberlite) are widely applied as adsorbents [191,192], In addition, the polystyrene-divinylbenzene resins functionalized with sulfuric acid (sulfonation) to create negatively charged sulfonic sites are applied as cation exchangers, and treated by chloromethylation followed by animation produce anionic resins [193,194],... 

The Merrifield resin, polystyrene-g-chloromethyl, or Wang resin can also be used as the polymeric substrate in the current invention. 

In the original Merrifield procedure, the ester linkage is prepared from the chloromethyl-functionalized polystyrene resin and the protected amino acid in the presence of a tertiary... 

The reaction of lithiated DBU 40 with chloromethylated or w-bromoalkylated polystyrene resins resulted in polystyrene-supported DBU... 

Products/technologies PL sells a range of combinatorial chemistry resins consisting of polystyrene resins with chloromethyl functionality (PL-CMS) for use in solid phase synthesis of peptides, small-molecule libraries, and other... 

Materials. Crosslinked polystyrene beads were purchased from Bio-Rad Laboratories and were dried under vacuo at 40 C. Merrifield resin (chloromethyl group content 0.9 meq/g) was purchased from Pierce Chemical Co. A series of 3-nitro-4-acyloxy-benzoic acids ( ) were prepared by methods described in the literature. The long-chain p-nitrophenyl ester substrates were purchased from Sigma Chemical Co. p-Nitrophenyl acetate was a product of Pierce Chemical Co. and sublimed in vacuo before being used. Polystyrene (average MW 22,000) was purchased from Aldrich Chemical Co. 

Early work on the application of NMR conventional techniques to the study of solvent swollen crosslinked polymers was reported by Stenlicht and co-workers [92] and Schaefer [93]. The first detailed work on the chlorome-thylated polystyrene resins used in solid phase synthesis appears to be by Manatt and co-workers [94]. They employed a 0.095% crosslinked species supplied by the Dow Chemical Co. and chloromethylated this to varying degrees. noise decoupled C NMR spectra were recorded in the usual... 

Fig. 15.4.60. C NMR spectra of chloromethylated polystyrene resins of 0-6% crosslink ratio swollen in CDCI3 (see Ref. 97).

Nucleophilic substitution of the chloromethylated cross-linked polystyrene resin has been used to attach a wide variety of groups. Among these are those shown (5.31) Potassium diphenylphosphide was used to make the first phosphine.131 The microenvironmental effects of this catalyst in the formation of benzyl benzoate by the Mit-... 

Belfer et al.157-161) reported that irreversible structural transformations take place during the chloromethylation of isoporous polystyrene resins. A styrene —... 

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