Polysaccharides hyaluronic acid

The final Klebsiella polysaccharide that will be mentioned specifically is KZS, whose chemical structure was determined by Niemann et al (24) (Figure 30). This polysaccharide is of particular interesT because its backbone consists of a similar alternating 1, 3 diequatorial, 1, 4 diequatorial glycosidic linkage geometry to that found in the connective tissue polysaccharides, hyaluronic acid, chondroitin sulphate and dermatan sulphate (25). All these three polysaccharides have exhibited 3-fold helical conformations with axially projected chemical repeats in the range 0.95 - 0.97 nm which is comparable to 0.97 nm found in K25 which also forms a 3-fold helix (14). Further, left-handed helices were found to be more favourable in K25 as has previously been observed in the connective tissue polysaccharides. The similarities between these various different structures is apparent in Figure 31 which shows projections down the axis of K25 and several of the connective tissue polysaccharides. 

Fessler, J.H. and Fessler, L.I., Electron microscopic visualization of the polysaccharide hyaluronic acid, Prvc. Natl Acad. Sci. USA, 56, 141, 1966. 

The average distance between charged sites can be estimated to be near 6 A, which makes about 1.2. As a comparison with other biological anionic polysaccharides, hyaluronic acid is less charged (b 20 A) while heparin is more (b 3 - 4 A). 

Naturally occurring polymers Polysaccharides Hyaluronic acid... 

Figure 20 Fluorinated polysaccharide-hyaluronic acid derivative containing oxadiazole moieties.

Lian et al. [123] investigated the polysaccharides, hyaluronic acid (HA) and sulfonated hyaluronic acid (SHA), as a suitable biomolecule to improve the surface biocompatibility of PPy films. The biological activity of the HA-functionalized PPY film was assessed by means of an in vitro PC12 cell... 

Markowitz, A. Dorfman, A. Synthesis of capsular polysaccharide (hyaluronic acid) by protoplast membrane preparations of group A streptoccocus J. Biol. Chem. 1962, 237, 273-279. 

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