Polysaccharide scaffold poly

In regenerative medicine, there are various different materials suitable as implantable scaffolds. These can be fabricated from natural or synthetic materials. Common examples are polysaccharides (eg, chitosan), or polyesters (eg, poly e-caprolactone), for natural and synthetic polymers, respectively. However, they are both capable of degradation (either enzyme mediated, or hydrolysis) in vivo (Bassi et al., 2011 Cunha-Reis et al., 2007). Often, polyesters are used as implantable biodegradable biomaterials, as they have controllable degradation and mechanical properties through formation of block copolymers. Where degradation occurs, the scaffolds... 

PHA solutions of various densities were used to prepare transparent flexible films. The surface properties of PHB and P(HB-co-HV) fllm scaffolds were similar to each other and to those of synthetic polyesters (polyethylene terephthalate, poly (methyl methacrylate), polyvinyl chloride, and polyethylene) (Shishatskaya 2(X)7X The scaffold s surface properties are important for cell attachment and proliferation. To enhance cell adhesion to the surface, improve the gas-dynamic properties of scaffolds, and increase their permeability for substrates and cell metabolites, the scaffolds can be treated by physical factors or by chemical reagents. Biocompatibility of PHA scaffolds has been enhanced by immobilizing collagen fllm matrices on the scaffold surface and coating with chitosan and chitosan/polysaccharides (Hu et al. 2003). 

Yamaguchi, N. and Kiick, K.L., Polysaccharide-poly(ethylene glycol) star copolymers as scaffolds for the production of bioactive hydrogels. Biomacromolecules 6,1921-30,2005. 

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