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Polysaccharide modification with anhydrides

One can of course ask why only PEG is chosen for protein modification instead of other polymers. Actually, very few examples of conjugation with other polymers have been reported so far, the most successful being the poly(styrene-co-maleic acid/anhydride) derivative of neocardnostatin (SMANCS) developed by Maeda [118]. The main reason Hes in the mono-functionahty of mPEG that avoids a cross-linking reaction with the polyfunc-tionalized proteins. The usual natural or synthetic polymers present multiple points of attachment in the same molecule. This is the case of polysaccharide, for instance, but also for the extensively studied poly(N-(2-hydroxypropyl) methacrylamide) copolymers (HPMA) [119]. [Pg.130]

See other pages where Polysaccharide modification with anhydrides is mentioned: [Pg.89]    [Pg.329]    [Pg.315]    [Pg.232]    [Pg.163]    [Pg.247]    [Pg.166]   
See also in sourсe #XX -- [ Pg.103 ]

See also in sourсe #XX -- [ Pg.91 ]

See also in sourсe #XX -- [ Pg.91 ]



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Anhydrides modification

Modification with

Polysaccharides modification

With anhydrides

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