Polysaccharide-based chiral

Figure 4.10 shows the effect of additive concentration on the separation of clen-buterol enantiomers on a polysaccharide-based chiral stationary phase [79]. The peak shapes were dramatically improved by adding an amine additive and the separation time was also reduced from 14 to 7 min when 1.0% amine was added to the mobile phase. Phinney and Sander [100] investigated the effect of amine additives using chiral stationary phases having either a macrocyclic glycopeptide or a... [Pg.227]

Yashima, E., Yamamoto, C., and Okamoto, Y. (1998) Polysaccharide-based chiral LC columns, Synlett, 344-360. [Pg.318]

Yashima, E. (2001) Polysaccharide-based chiral stationary phases for high-performance liquid chromatographic enantioseparation, J. Chromatogr. A 906, 105-125. [Pg.319]

R590 E. Yashima, Polysaccharide-Based Chiral Stationary Phases for High-Performance Liquid Chromatographic Enantioseparation , J. Chroma-togr.. A, 2001,906,105... [Pg.40]

FIGURE 144 (A) Achiral- and (B) chiral-method screen strategies. (A) Platform 1 (HPLC-1) uses two different mobile phases, one is acidic (mobile phase 1) and another is neutral-to-basic (mobile phase 2) to screen on two columns, a classic reverse-phase C-18 and a special polar group-embedded C-18 (AQ). Platform-2 (HPLC-2) uses one mobile phase (pH is usually acidic) to screen four different columns of wide range of polarity (PFP fluorinated, and Phen phenyl-hexyl phases). Platform-3 (SFC) uses three different mobile phases and five different columns (PYD 2-ethylpyridine, BENZ benzamide). Platform-4 (CE) uses two different mobile phases. (B) AD, OJ, OD, AS are different polysaccharide-based chiral stationary phases. [Pg.412]

Zhang, T, Schaeffer, M and Franco, P. (2005a) Optimization of the chiral separation of a Ca-sensitizing drug on an immobilized polysaccharide-based chiral stationary phase. Case study with a preparative perspective. /. Chromatogr. A, 1083, 96-101. [Pg.197]

R.C. Polysaccharide-based chiral phase under polar organic mode of elution in the determination of the enantiomeric purity of emtricitabine an anti-HIV analogue nucleoside. 19. J. Pharm. Biomed. Anal. 2003, 33 (4), 581 587. [Pg.117]

Lomsadze K, Jibuti G, Farkas T, Chankvetadze B. Comparative high-performance liquid chromatography enantioseparations using polysaccharide based chiral stationary phases prepared by coating of totally porous and core-shell silica particles. J Chromatogr A 2012 1234 50-55. [Pg.90]

TABLE I Polysaccharide-Based Chiral Columns Commonly Used in Pharmaceutical HPLC Method Development Screening Systems... [Pg.255]

Kasat RB, Wang NHL, Franses FI (2008) Experimental probing and modeling of key sorbent-solute interactions of norephedrine enantiomers with polysaccharide-based chiral stationary phases. J Chromatogr A 1190 110-119... [Pg.52]

Mitchell CR, Armstrong DW (2004) Cyclodextrin-based chiral stationary phases for liquid chromatography a twenty-year overview. In Giibitz G, Schmid MG (eds) Chiral separations methods and protocols, methods in molecular biology, vol 243, Humana press, Totowa, NJ Ikai T, Yamamoto C, Kamigaito M, Okamoto Y (2006) Immobilized polysaccharide-based chiral stationary phases for HPLC. Polym J 38 91-108... [Pg.96]

Thunberg L, Hashemi J, Andersson S (2008) Comparative study of coated and immobilized polysaccharide-based chiral stationary phases and their applicability in the resolution of enantiomers. J Chromatogr B 875 72-80... [Pg.193]

Ye YK, Stringham RW (2006) The effect of acidic and basic additives on the enan-tioseparation of basic drugs using polysaccharide-based chiral stationary phases. Chirality... [Pg.198]

Zhang T, Nguyen D, Franco P. Enantiomer resolution screening strategy using multiple immobilised polysaccharide-based chiral stationary phases. J. Chromatogr. A 2008 1191 214-222. [Pg.1623]

Ma S, Shen S, Lee H, Eriksson M, Zeng X, Xu J, Eandrick K, Yee N, Senanayake C, Grinberg N. Mechanistic studies on the chiral recognition of polysaccharide-based chiral stationary phases using liquid chromatography and vibrational circular dichroism. Reversal of elution order of iV-substituted alpha-methyl phenylalanine esters. J. Chromatogr. A 2009 1216 3784-3793. [Pg.1623]

Aranyi A, Ilisz I, Pataj Z, Szatmari I, Fiilop F, Peter A. High-performance liquid chromatographic enantioseparation of 1-(phenylethylamino)- or l-(naphthylethylamino)methyl-2-naphthol analogs and a temperature-induced inversion of the elution sequence on polysaccharide-based chiral stationary phases. J. Chromatogr. A 2011 1218 4869 876. [Pg.1625]

Yao B, Zhan F, Yu G, Chen Z, Fan W, Zeng X, Zeng Q, Weng W. Temperature-induced inversion of elution order in the chromatographic enantioseparation of l,l -bi-2-naphthol on an immobilized polysaccharide-based chiral stationary phase. J. Chromatogr. A 2009 1216 5429-5435. [Pg.1625]

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