Polyol sorbitol

Glycerol, polyols (sorbitol, mannitol) Solvophobicity Affinity for polar regions Stabilizers of globular proteins and assembled organelles, decreasing for proteins of high polarity... 

Many excipients used by the pharmaceutical industry in the last 15 years in sugar-free medical preparations probably come under the category of essentially new excipients. Pressure for their introduction has been encouraged by the definite relationship between the dietary consumption of sucrose and the incidence of dental caries. " "" These materials include intense sweeteners such as saccharin and cyclamate plus bulk sweeteners such as the polyols sorbitol, xylitol, and lactitol. These materials are all either approved for food use or have pharmacopoeia monographs in existence or in draft. Fiterature reviews show number of... 

The mixtures of sucrose - triethanolamine, usually of 1-1.5/1 (sucrose/triethanolamine) [9] are very stirrable mixtures, at the propoxylation temperature, and are frequently used in practice. Triethanolamine can be replaced by diethanolamine, monoethanolamine and even by ammonia [59]. The triol is formed in situ by the reaction of ammonia or primary or secondary ethanolamines with PO. The polyols based on sucrose - triethanolamine (Table 13.6) are frequently used to make rigid PU foams for thermoinsulation of freezers. The mixtures of sucrose - sorbitol lead easily to high functionality polyols, sorbitol having an excellent solvating capability for solid sucrose. 

By the hydrogenation of D-glucose, a hexafunctional polyol, sorbitol is obtained, one of the most important starters to initiate the polymerisation of propylene oxide (PO) to hexafunctional rigid polyether polyols. 

To coimter the loss of water dining the process and a significant degradation of the material, to prevent, e.g., the formation of cellular stractures output from an extruder, and to obtain a material with controlled properties, we use a non-volatile plasticizer such as glycerol or other polyols (sorbitol, xylitol, fructose, polyethylene glycol, etc.) [AVE 04a, XIE 12]. Blends of these different polyols are also used [CHI 10b]. Other, notably nitrogenous plasticizers (urea, ammonium derivatives, amines, etc.) can also be used. Plasticized starches are thus created. They are... 

The supramolecular systems with nanosilica, proteins, and monosugars or disaccharides can possess a high bioactivity and be used in bionanocomposites perspective for biotechnology and medicine (Devis and Robinson 2002, Chuiko 2003). It was shown that composites on the basis of nanosilica, BSA, polyol (sorbitol, xylitol), or monosaccharides (fructose, glucose) in wide range of concentrations can stimulate activity and prolong lifetime of cells after their cryopreservation. 

Polyols Sorbitol (available as sorbitol solution 70 %), mannitol, xylitol, glycerol... 

The removal of polyols, sorbitol and xylitol from the blood of newborns does not differ from that of adults (Bassler et al., 1962 Toussaint, 1969). Therefore, these polyols can also be used with amino acid solutions for the parenteral nutrition of premature infants (Griem and Lang, 1962 Lang, 1963 Mehnert, 1966 Prellwitz and Bassler, 1963). 

Unsaturation within the fatty acid chain did not disturb the process. In the polymerisation of divinyl sebacate and polyol (sorbitol), the regioselectivity was controlled to yield sugar-containing polyesters in which the 1- and 6-positions of sorbitol were regioselectively acylated. 

Aldose reductase converts aldoses, such as glucose and galactose, into polyols (sorbitol, galactitol). Inhibitors of this en2yme could be used to combat diabetes. 

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