Polymorphisms, transporters

Keywords ABCBl ABCCl ABCC2 ABCG2 OATPIBI OATP1B3 polymorphisms transport. 

Niemi M, Pasanen MK, Neuvonen PJ (2011) Organic anion transporting polypeptide 1B1 a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev 63 157-181... 

Transferrin (Tf) is a Pj-globulin with a molecular mass of approximately 76 kDa. it is a glycoprotein and is synthesized in the liver. About 20 polymorphic forms of transferrin have been found, it plays a central role in the body s metabolism of iron because it transports iron (2 mol of Fe + per mole of Tf) in the circulation to sites where iron is required, eg, from the gut to the bone marrow and other organs. Approximately 200 billion red blood cells (about 20 mL) are catabolized per day, releasing about 25 mg of iron into the body—most of which will be transported by transferrin. 

Genetic polymorphisms in gene encoding receptors, transporters, or other therapeutic targets... 

Arias, B., Catalan, R. et al. (2003). 5-HTTLPR polymorphism of the serotonin transporter gene predicts non-remission in major depression patients treated with citalopram in a 12-weeks follow up study. /. Clin. Psychopharmacol, 23(6), 563-7. 

Kim, H., Lim, S. W.et al. (2006). Monoamine transporter gene polymorphisms and antidepressant response in Koreans with late-life depression. JAMA, 296(13), 1609-18. 

Smeraldi, E., Zanardi, R. et al. (1998). Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol. Psychiatry, 3(6), 508-11. Wang, S. L., Huang, J. D. et al. (1993). Molecular basis of genetic variation in debrisoquin hydroxylation in Chinese subjects polymorphism in RFLP and DNA sequence of CYP2D6. Clin. Pharmacol. Ther., 53(4), 410-18. 

Yoshida, K., Ito, K. etal. (2002). Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients. Prog. Neuropsychopharmacol. Biol. Psychiatry, 26(2), 383-6. 

Yu, Y. W., Tsai, S. J. etal. (2002). Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders. Mol. Psychiatry, 7(10), 1115-19. 

Kim, D.K.et al. (2000). Serotonin transporter gene polymorphism and antidepressant response. Neuroreport, 11,215-19. 

Ng, C. H., Easteal, S., Tan, S. et al. (2006b). Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities. Progress in Neuropsychopharmacology and Biological... 

Smeraldi, E. et al. (1998). Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol. Psychiatry, 3, 508-11. 

Durham, L. K., Webb, S. M., Milos, P. M., Clary, C. M. Seymour, A. B. (2004). The serotonin transporter polymorphism, 5HTTLPR, is associated with a faster response time to sertraline in an elderly population with major depressive disorder. Psychopharmacology, 174, 525-9. 

Lesch, K. P., Bengel, D., Heils, A. etal. (1996). Association of anxiety related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527-31. 

Minov, C., Baghai, T.C., Schule, C. etal. (2001). Serotonin-2A-receptor and -transporter polymorphisms lack of association in patients with major depression. Neurosci. Lett., 303, 119-22. 

Yoshida, K., Takahashi, H., Higuchi, H. etal. (2004). Prediction of antidepressants response to milnacipran by norepinephrine transporter gene polymorphisms. Am. J. Psychiatry, 161(9), 1575-80. 

Zanardi, R., Benedetti, F., Di Bella, D., Catalano, M. Smeraldi, E. (2000). Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. /. Clin. Psychopharmacol., 20, 105-7. 

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