Polymers ester-linked conjugates

It is anticipated that in the coming years, a number of HA-derivatives will appear for clinical application in Dermatology that contain cross-linked HA polymers as well as HA-ester derivatives obtained by the conjugation of the carboxylic acid of HA with various drugs in their alcohol forms. The HA polymer, because of its intrinsic biocompatibility, reactivity, and degradability, will have many uses in the rapidly expanding field of tissue engineering and in the tissue substitutes of the future. 

Another approach is to occlude into the electroconductive polymer film a second polymer that contains functionalities to which indicator molecules may be conveniently covalently attached. Guiseppi-Elie and Wilson [180] coelectropolymerized pyrrole and 3-(l-pyrrolyl)-propionic acid in the presence of poly(styrenesuIfonic acid) and polyvinylamine (PVAm). Incorporation of the PV Am into the polymer film confers free primary amines on the surface of the film. Using aqueous cross-linking chemistry Guiseppi-Elie and Wilson conjugated the suc-cinamide ester of NHS-LC-biotin to the primary amine sites of the polymer surface. A simple variation on this theme can produce a wide variety of chemical and biological sensors. The occlusion of human serum albumin (HSA) [154] or bovine serum albumin (BSA) by electropolymerization in electroconductive polymer can also provide —COOH, —NH2, and —SH sites for the convenient attachment of indicator molecules. Likewise, macromolecular counteranions may be functionalized prior to or following occlusion into the CEP membrane. 

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